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Neoplastic Hematopathology: WHO 2016にそった分類による

 

Myeloid neoplasms and acute leukemia

Myeloproliferative neoplasms

  • Chronic myeloid leukemia (CML), BCR-ABL1+
  • Chronic neutrophilic leukemia (CNL)
  • Primary myelofibrosis (PMF)
  • PMF, prefibrotic/early stage
  • PMF, overt fibrotic stage
  • Chronic eosinophilic leukaemia, not otherwise specified
  • MPN, unclassifiable

Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1

  • Myeloid/lymphoid neoplasms with PDGFRB rearrangement
  • Myeloid/lymphoid neoplasms with FGFR1 rearrangement
  • Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2

Myelodysplastic/ Myeloproliferative neoplasms

  • Atypical chronic myeloid leukemia (aCML), BCR-ABL-
  • MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)
  • MDS/MPN, unclassifiable

Myelodysplastic syndromes

  • 骨髄異形成症候群 Myelodysplastic syndrome(MDS)WHO 4thEd分類
  • MDS up-to date; 第2回東日本骨髄病理研究会講演
  • MDS with single lineage dysplasia
  • MDS with ring sideroblasts (MDS-RS)
  • MDS-RS and single lineage dysplasia
  • MDS-RS and multilineage dysplasia
  • MDS with multilineage dysplasia
  • MDS with excess blasts
  • MDS, unclassifiable
  • Provisional entity: Refractory cytopenia of childhood

Acute myeloid leukaemia(AML) and related precursor neoplams

Acute luekaemia with ambiguous lineage

lymphoid neoplasms WHO2016

Precursor lymphoid neoplasmas

Mature B-cell neoplasms

  • Monoclonal B-cell lymphocytosis*
  • B-cell prolymphocytic leukemia
  • Splenic marginal zone lymphoma
  • Hairy cell leukemia
  • Splenic B-cell lymphoma/leukemia, unclassifiable
  • Splenic diffuse red pulp small B-cell lymphoma
  • Hairy cell leukemia-variant
  • Monoclonal gammopathy of undetermined significance (MGUS), IgM*
  • μ heavy-chain disease
  • γ heavy-chain disease
  • α heavy-chain disease
  • Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*
  • Plasma cell myeloma
  • Solitary plasmacytoma of bone
  • Extraosseous plasmacytoma
  • Monoclonal immunoglobulin deposition diseases*
  • Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
  • Nodal marginal zone lymphoma
  • Pediatric nodal marginal zone lymphoma
  • Follicular lymphoma
  • In situ follicular neoplasia*
  • Duodenal-type follicular lymphoma*
  • Pediatric-type follicular lymphoma*
  • Large B-cell lymphoma with IRF4 rearrangement*
  • Primary cutaneous follicle center lymphoma
  • Mantle cell lymphoma
  • In situ mantle cell neoplasia*
  • Diffuse large B-cell lymphoma (DLBCL), NOS
  • Germinal center B-cell type*
  • Activated B-cell type*
  • T-cell/histiocyte-rich large B-cell lymphoma
  • Primary DLBCL of the central nervous system (CNS)
  • Primary cutaneous DLBCL, leg type
  • EBV+ DLBCL, NOS*
  • EBV+ mucocutaneous ulcer*
  • DLBCL associated with chronic inflammation
  • Primary mediastinal (thymic) large B-cell lymphoma
  • Intravascular large B-cell lymphoma
  • Plasmablastic lymphoma
  • Primary effusion lymphoma
  • HHV8+ DLBCL, NOS*
  • Burkitt lymphoma
  • Burkitt-like lymphoma with 11q aberration*
  • High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*
  • High-grade B-cell lymphoma, NOS*
  • B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

Mature T- and NK-cell neoplasms

  • T-cell prolymphocytic leukemia
  • T-cell large granular lymphocytic leukemia
  • Chronic lymphoproliferative disorder of NK cells
  • Aggressive NK-cell leukemia
  • Systemic EBV+ T-cell lymphoma of childhood*
  • Hydroa vacciniforme-like lymphoproliferative disorder*
  • Adult T-cell leukemia/lymphoma
  • Enteropathy-associated T-cell lymphoma
  • Monomorphic epitheliotropic intestinal T-cell lymphoma*
  • Indolent T-cell lymphoproliferative disorder of the GI tract*
  • Hepatosplenic T-cell lymphoma
  • Subcutaneous panniculitis-like T-cell lymphoma
  • Mycosis fungoides
  • Sezary syndrome
  • Primary cutaneous CD30+ T-cell lymphoproliferative disorders
  • Lymphomatoid papulosis
  • Primary cutaneous anaplastic large cell lymphoma
  • Primary cutaneous γδ T-cell lymphoma
  • Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
  • Primary cutaneous acral CD8+ T-cell lymphoma*
  • Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*
  • Peripheral T-cell lymphoma, NOS
  • Angioimmunoblastic T-cell lymphoma
  • Follicular T-cell lymphoma*
  • Nodal peripheral T-cell lymphoma with TFH phenotype*
  • Anaplastic large-cell lymphoma, ALK-*
  • Breast implant-associated anaplastic large-cell lymphoma*

Hodgkin lymphoma

Hodgkin lymphoma

  • Nodular lymphocyte predominant Hodgkin lymphoma
  • Classical Hodgkin lymphoma
    • Nodular sclerosis classical Hodgkin lymphoma
    • Lymphocyte-rich classical Hodgkin lymphoma
    • Mixed cellularity classical Hodgkin lymphoma
    • Lymphocyte-depleted classical Hodgkin lymphoma

Posttransplant lymphoproliferative disorders (PTLD) WHO2016

  • Plasmacytic hyperplasia PTLD
  • Infectious mononucleosis PTLD
  • Florid follicular hyperplasia PTLD*
  • Polymorphic PTLD
  • Monomorphic PTLD (B- and T-/NK-cell types)
  • Classical Hodgkin lymphoma PTLD

Histiocytic and dendritic cell neoplasms

  • Histiocytic sarcoma
  • Langerhans cell histiocytosis
  • Langerhans cell sarcoma
  • Indeterminate dendritic cell tumor
  • Interdigitating dendritic cell sarcoma
  • Follicular dendritic cell sarcoma
  • Fibroblastic reticular cell tumor
  • Disseminated juvenile xanthogranuloma
  • Erdheim-Chester disease*

血液腫瘍病理学のお勉強

日本病理学会

日本血液病理研究会

日本網内系学会

リンパ腫スキルアップセミナー

日本病理学会中部支部交見会血液関連症例

日本病理学会中部支部スライドセミナ血液関連セミナ

日本血液学会

日本血液学会公式ホームページ クリックで移動

東京骨髄病理研究会

東京骨髄病理研究会の管理人まとめページ

第6回東京骨髄病理研究会

第5回東京骨髄病理研究会

第4回東京骨髄病理研究会

第3回東京骨髄病理研究会

第2回東京骨髄病理研究会

第1回東京骨髄病理研究会

関東リンパ腫診断研究会(リンフォマニアの会)

リンフォマニアになるためのリンパ腫病理診断コース

東海大学公式のリンフォマニアになるためのリンパ腫病理診断コースホームページ クリックで移動

Mature B-cell neoplasms

  • Chronic lymphocytic leukemia/small lymphocytic lymphoma
  • Monoclonal B-cell lymphocytosis*
  • B-cell prolymphocytic leukemia
  • Splenic marginal zone lymphoma
  • Hairy cell leukemia
  • Splenic B-cell lymphoma/leukemia, unclassifiable
  • Splenic diffuse red pulp small B-cell lymphoma
  • Hairy cell leukemia-variant
  • Lymphoplasmacytic lymphoma
  • Waldenstrom macroglobulinemia
  • Monoclonal gammopathy of undetermined significance (MGUS), IgM*
  • μ heavy-chain disease
  • γ heavy-chain disease
  • α heavy-chain disease
  • Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*
  • Plasma cell myeloma
  • Solitary plasmacytoma of bone
  • Extraosseous plasmacytoma
  • Monoclonal immunoglobulin deposition diseases*
  • Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
  • Nodal marginal zone lymphoma
  • Pediatric nodal marginal zone lymphoma
  • Follicular lymphoma
  • In situ follicular neoplasia*
  • Duodenal-type follicular lymphoma*
  • Pediatric-type follicular lymphoma*
  • Large B-cell lymphoma with IRF4 rearrangement*
  • Primary cutaneous follicle center lymphoma
  • Mantle cell lymphoma
  • In situ mantle cell neoplasia*
  • Diffuse large B-cell lymphoma (DLBCL), NOS
  • Germinal center B-cell type*
  • Activated B-cell type*
  • T-cell/histiocyte-rich large B-cell lymphoma
  • Primary DLBCL of the central nervous system (CNS)
  • Primary cutaneous DLBCL, leg type
  • EBV+ DLBCL, NOS*
  • EBV+ mucocutaneous ulcer*
  • DLBCL associated with chronic inflammation
  • Lymphomatoid granulomatosis
  • Primary mediastinal (thymic) large B-cell lymphoma
  • Intravascular large B-cell lymphoma
  • ALK+ large B-cell lymphoma
  • Plasmablastic lymphoma
  • Primary effusion lymphoma
  • HHV8+ DLBCL, NOS*
  • Burkitt lymphoma
  • Burkitt-like lymphoma with 11q aberration*
  • High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*
  • High-grade B-cell lymphoma, NOS*
  • B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

Mature T and NK neoplasms

  • T-cell prolymphocytic leukemia
  • T-cell large granular lymphocytic leukemia
  • Chronic lymphoproliferative disorder of NK cells
  • Aggressive NK-cell leukemia
  • Systemic EBV+ T-cell lymphoma of childhood*
  • Hydroa vacciniforme-like lymphoproliferative disorder*
  • Adult T-cell leukemia/lymphoma
  • Extranodal Natural Killer(NK)/T-Cell Lymphoma, Nasal Type
  • Enteropathy-associated T-cell lymphoma
  • Monomorphic epitheliotropic intestinal T-cell lymphoma*
  • Indolent T-cell lymphoproliferative disorder of the GI tract*
  • Hepatosplenic T-cell lymphoma
  • Subcutaneous panniculitis-like T-cell lymphoma
  • Mycosis fungoides
  • Sezary syndrome
  • Primary cutaneous CD30+ T-cell lymphoproliferative disorders
    • Lymphomatoid papulosis
    • Primary cutaneous anaplastic large cell lymphoma
  • Primary cutaneous γδ T-cell lymphoma
  • Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
  • Primary cutaneous acral CD8+ T-cell lymphoma*
  • Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*
  • Peripheral T-cell lymphoma, NOS
  • Angioimmunoblastic T-cell lymphoma
  • Follicular T-cell lymphoma*
  • Nodal peripheral T-cell lymphoma with TFH phenotype*
  • Anaplastic large-cell lymphoma, ALK+
  • Anaplastic large-cell lymphoma, ALK-*
  • Breast implant-associated anaplastic large-cell lymphoma* Hodgkin lymphoma
  • Nodular lymphocyte predominant Hodgkin lymphoma
  • Classical Hodgkin lymphoma
    • Nodular sclerosis classical Hodgkin lymphoma
    • Lymphocyte-rich classical Hodgkin lymphoma
    • Mixed cellularity classical Hodgkin lymphoma
    • Lymphocyte-depleted classical Hodgkin lymphoma Posttransplant lymphoproliferative disorders (PTLD)
  • Plasmacytic hyperplasia PTLD
  • Infectious mononucleosis PTLD
  • Florid follicular hyperplasia PTLD*
  • Polymorphic PTLD
  • Monomorphic PTLD (B- and T-/NK-cell types)
  • Classical Hodgkin lymphoma PTLD Histiocytic and dendritic cell neoplasms
  • Histiocytic sarcoma
  • Langerhans cell histiocytosis
  • Langerhans cell sarcoma
  • Indeterminate dendritic cell tumor
  • Interdigitating dendritic cell sarcoma
  • Follicular dendritic cell sarcoma
  • Fibroblastic reticular cell tumor
  • Disseminated juvenile xanthogranuloma
  • Erdheim-Chester disease*

Lymphomatoid granulomatosis SPS218-Case01

Myeloproliferative neoplasms (MPN)

  • Chronic myeloid leukemia (CML), BCR-ABL1+
  • Chronic neutrophilic leukemia (CNL)
  • Polycythemia vera (PV)
  • Primary myelofibrosis (PMF)
  • PMF, prefibrotic/early stage
  • PMF, overt fibrotic stage
  • Essential thrombocythemia (ET)
  • Chronic eosinophilic leukemia, not otherwise specified (NOS)
  • MPN, unclassifiable

Mastocytosis

Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2

  • Myeloid/lymphoid neoplasms with PDGFRA rearrangement
  • Myeloid/lymphoid neoplasms with PDGFRB rearrangement
  • Myeloid/lymphoid neoplasms with FGFR1 rearrangement
  • Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2

Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

  • Chronic myelomonocytic leukemia (CMML)
  • Atypical chronic myeloid leukemia (aCML), BCR-ABL1-
  • Juvenile myelomonocytic leukemia (JMML)
  • MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)
  • MDS/MPN, unclassifiable

Myelodysplastic syndromes (MDS)

  • MDS with single lineage dysplasia
  • MDS with ring sideroblasts (MDS-RS)
  • MDS-RS and single lineage dysplasia
  • MDS-RS and multilineage dysplasia
  • MDS with multilineage dysplasia
  • MDS with excess blasts
  • MDS with isolated del(5q)
  • MDS, unclassifiable
  • Provisional entity: Refractory cytopenia of childhood

Myeloid neoplasms with germ line predisposition

Acute myeloid leukemia (AML) and related neoplasms

  • AML with recurrent genetic abnormalities
  • AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1
  • AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFB-MYH11
  • APL with PML-RARA
  • AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A
  • AML with t(6;9)(p23;q34.1);DEK-NUP214
  • AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM
  • AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1
  • Provisional entity: AML with BCR-ABL1
  • AML with mutated NPM1
  • AML with biallelic mutations of CEBPA
  • Provisional entity: AML with mutated RUNX1
  • AML with myelodysplasia-related changes
  • Therapy-related myeloid neoplasms
  • AML, NOS
  • AML with minimal differentiation
  • AML without maturation
  • AML with maturation
  • Acute myelomonocytic leukemia
  • Acute monoblastic/monocytic leukemia
  • Pure erythroid leukemia
  • Acute megakaryoblastic leukemia
  • Acute basophilic leukemia
  • Acute panmyelosis with myelofibrosis
  • Myeloid sarcoma
  • Myeloid proliferations related to Down syndrome
  • Transient abnormal myelopoiesis (TAM)
  • Myeloid leukemia associated with Down syndrome

Blastic plasmacytoid dendritic cell neoplasm

Acute leukemias of ambiguous lineage

  • Acute undifferentiated leukemia
  • Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR-ABL1
  • MPAL with t(v;11q23.3); KMT2A rearranged
  • MPAL, B/myeloid, NOS
  • MPAL, T/myeloid, NOS

B-lymphoblastic leukemia/lymphoma

  • B-lymphoblastic leukemia/lymphoma, NOS
  • B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities
  • B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2);BCR-ABL1
  • B-lymphoblastic leukemia/lymphoma with t(v;11q23.3);KMT2A rearranged
  • B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1
  • B-lymphoblastic leukemia/lymphoma with hyperdiploidy
  • B-lymphoblastic leukemia/lymphoma with hypodiploidy
  • B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3) IL3-IGH
  • B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1
  • Provisional entity: B-lymphoblastic leukemia/lymphoma, BCR-ABL1-like
  • Provisional entity: B-lymphoblastic leukemia/lymphoma with iAMP21

T-lymphoblastic leukemia/lymphoma

  • Provisional entity: Early T-cell precursor lymphoblastic leukemia

Provisional entity: Natural killer (NK) cell lymphoblastic leukemia/lymphoma


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Last-modified: 2018-02-24 (土) 13:25:51 (172d)