Testicular germ cell tumors -- 睾丸胚細胞性腫瘍

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睾丸胚細胞性腫瘍　Testicular germ cell tumors †

免疫染色による睾丸胚細胞性腫瘍の鑑別診断(右図)

WHO (2016) classification

Germ cell tumors derived from germ cell neoplasia in situ †

Noninvasive germ cell neoplasia

• Germ cell neoplasia in situ
• Specific forms of intratubular germ cell neoplasia

Tumors of a single histological type (pure forms)

• Seminoma
• Seminoma with syncytiotrophoblast cells

Nonseminomatous germ cell tumors

• Embryonal carcinoma
• Yolk sac tumor, postpubertal type
• Trophoblastic tumors
  • Choriocarcinoma
  • Nonchoriocarcinomatous trophoblastic tumors
  • Placental site trophoblastic tumor
  • Epithelioid trophoblastic tumor
  • Cystic trophoblastic tumor
• Teratoma, postpubertal type
• Teratoma with somatic type malignancy

Nonseminomatous germ cell tumors of more than one histological type

• Mixed germ cell tumors Germ cell tumors of unknown type
• Regressed germ cell tumors

Germ cell tumors unrelated to germ cell neoplasia in situ

Spermatocytic tumor

Teratoma, prepubertal type

• Dermoid cyst
• Epidermoid cyst
• Well differentiated neuroendocrine tumor (monodermal teratoma)

Mixed teratoma and yolk sac tumor, prepubertal type

Yolk sac tumor, prepubertal type