[[WikiPathologica]]

*Neoplastic Hematopathology: WHO 2016にそった分類による [#i95d1005]
#br

*Myeloid neoplasms and acute leukemia [#ne538a5d]

**Myeloproliferative neoplasms [#k446232c]

-[[JAK/STATシグナリング]]

-Chronic myeloid leukemia (CML), BCR-ABL1+

-Chronic neutrophilic leukemia (CNL)

-[[Polycythemia vera (PV)>Polycythemia vera 真性多血症]]

-Primary myelofibrosis (PMF)

--PMF, prefibrotic/early stage

--PMF, overt fibrotic stage

-Essential thrombocythemia (ET)-->[[%%%本態性血小板血症%%%>Essential thromobocythemia 本態性血小板血症]], [[%%%MPL遺伝子とtriple-negative ET%%%>MPL proto-oncogene, thrombopoietin receptor (MPL)]], [[%%%MPNsの遺伝子変異;canonical gene mutations%%%>thrombopoietin receptor (MPL) gene mutation in patients with Myeloproliferative neoplasm]]

-Chronic eosinophilic leukaemia, not otherwise specified

-MPN, unclassifiable

**Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1 [#v4d76ab3]

-[[Myeloid/lymphoid neoplasms with '''PDGFRA''' rearrangement>eosinophiliaが著明な骨髄増殖性腫瘍]]---疾患解説と症例のページあり.

-Myeloid/lymphoid neoplasms with PDGFRB rearrangement

-Myeloid/lymphoid neoplasms with FGFR1 rearrangement

-Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2

**Myelodysplastic/ Myeloproliferative neoplasms [#x1958384]

-[[Chronic myelomonocytic leukaemia (CMML)]]

-Atypical chronic myeloid leukemia (aCML), BCR-ABL-

-Juvenile myelomonocytic leukemia (JMML)
-[[Juvenile myelomonocytic leukemia (JMML)>Juvenile myelomonocytic leukemia 若年性骨髄単球性白血病]]---疾患解説ページ

-MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)

-MDS/MPN, unclassifiable


**Myelodysplastic syndromes [#u752a090]

-[[骨髄異形成症候群 Myelodysplastic syndrome(MDS)WHO 4thEd分類>骨髄異形成症候群 Myelodysplastic syndrome(MDS)]]

-[[MDS up-to date; 第2回東日本骨髄病理研究会講演>第2回東日本骨髄病理研究会#o452411c]] 

-[[MDSに認められる染色体異常>MDSに認められる染色体異常]]

-[[MDSの遺伝子異常-エピジェネティック制御因子をコードする遺伝子の異常>MDSの遺伝子異常-エピジェネティック制御因子をコードする遺伝子の異常]]

-[[MDSの遺伝子異常-pre-mRNAスプライシング機構に関わる遺伝子群の異常>MDSの遺伝子異常-pre-mRNAスプライシング機構に関わる遺伝子群の異常]]

-[[MDS associated with isolated del(5q)>MDS associated with isolated del(5q)]]:Ribosomal protein S14(RPS14), およびmicroRNAのmiR-145, miR-146a ハプロ不全

-[[MDS up-to-date: 名古屋第一赤十字病院伊藤雅文先生の講演から>第2回東京骨髄病理研究会#o452411c]]
#br

-MDS with single lineage dysplasia

-MDS with ring sideroblasts (MDS-RS)

--MDS-RS and single lineage dysplasia

--MDS-RS and multilineage dysplasia

-MDS with multilineage dysplasia

-MDS with excess blasts

-[[MDS with isolated del(5q)>MDS associated with isolated del(5q)]]

-MDS, unclassifiable

-Provisional entity: Refractory cytopenia of childhood

**Acute myeloid leukaemia(AML) and related precursor neoplams [#l2340d6e]
-[[MLL Mixed-Lineage Leukemia Gene]]

-[[FLT3 mutationをもつ Leukemia>FLT3]]

**Acute luekaemia with ambiguous lineage [#uac6e060]
-[[MLL Mixed-Lineage Leukemia Gene]]


*lymphoid neoplasms  WHO2016 [#mf35b929]

**Precursor lymphoid neoplasmas [#d757a831]

**Mature B-cell neoplasms [#w3b63de3]

-[[Chronic lymphocytic leukemia/small lymphocytic lymphoma>CLL/SLL]]

-Monoclonal B-cell lymphocytosis*

-B-cell prolymphocytic leukemia

-Splenic marginal zone lymphoma

-Hairy cell leukemia

-Splenic B-cell lymphoma/leukemia, unclassifiable

--Splenic diffuse red pulp small B-cell lymphoma

--Hairy cell leukemia-variant

-[[Lymphoplasmacytic lymphoma>lymphoplasmacytic lymphoma(LPL)]]

--[[Waldenstrom macroglobulinemia>Waldenstroem macroglobulinemia]]

-Monoclonal gammopathy of undetermined significance (MGUS), IgM*

-μ heavy-chain disease

-γ heavy-chain disease

-α heavy-chain disease

-Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*

-Plasma cell myeloma

-Solitary plasmacytoma of bone

-Extraosseous plasmacytoma

-Monoclonal immunoglobulin deposition diseases*

-Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)

-Nodal marginal zone lymphoma

--Pediatric nodal marginal zone lymphoma

-Follicular lymphoma

--In situ follicular neoplasia*

--Duodenal-type follicular lymphoma*

-Pediatric-type follicular lymphoma*

-Large B-cell lymphoma with IRF4 rearrangement*

-Primary cutaneous follicle center lymphoma

-Mantle cell lymphoma

--In situ mantle cell neoplasia*

-Diffuse large B-cell lymphoma (DLBCL), NOS

--Germinal center B-cell type*

--Activated B-cell type*

-T-cell/histiocyte-rich large B-cell lymphoma

-Primary DLBCL of the central nervous system (CNS)

-Primary cutaneous DLBCL, leg type

-EBV+ DLBCL, NOS*

-EBV+ mucocutaneous ulcer*

-DLBCL associated with chronic inflammation

-[[Lymphomatoid granulomatosis>Lymphomatoid granulomatosis SPS218-Case01]]

-Primary mediastinal (thymic) large B-cell lymphoma

-Intravascular large B-cell lymphoma

-[[ALK+ large B-cell lymphoma>ALK-positive large B-cell lymphoma]] (WHO2008,2016)

-Plasmablastic lymphoma

-Primary effusion lymphoma

-HHV8+ DLBCL, NOS*

-Burkitt lymphoma

-Burkitt-like lymphoma with 11q aberration*

-High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*

-High-grade B-cell lymphoma, NOS*

-B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma



**Mature T- and NK-cell neoplasms [#heed057b]

-T-cell prolymphocytic leukemia

-T-cell large granular lymphocytic leukemia

-Chronic lymphoproliferative disorder of NK cells

-Aggressive NK-cell leukemia

-Systemic EBV+ T-cell lymphoma of childhood*

-Hydroa vacciniforme-like lymphoproliferative disorder*

-Adult T-cell leukemia/lymphoma

-[[Extranodal Natural Killer(NK)/T-Cell Lymphoma, Nasal Type]]

-Enteropathy-associated T-cell lymphoma

-Monomorphic epitheliotropic intestinal T-cell lymphoma*

-Indolent T-cell lymphoproliferative disorder of the GI tract*

-Hepatosplenic T-cell lymphoma

-Subcutaneous panniculitis-like T-cell lymphoma

-Mycosis fungoides

-Sezary syndrome

-Primary cutaneous CD30+ T-cell lymphoproliferative disorders

--Lymphomatoid papulosis

--Primary cutaneous anaplastic large cell lymphoma

-Primary cutaneous γδ T-cell lymphoma

-Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma

-Primary cutaneous acral CD8+ T-cell lymphoma*

-Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*

-Peripheral T-cell lymphoma, NOS

-Angioimmunoblastic T-cell lymphoma

-Follicular T-cell lymphoma*

-Nodal peripheral T-cell lymphoma with TFH phenotype*

-[[Anaplastic large-cell lymphoma, ALK+>Anaplastic large cell lymphoma(ALCL), ALK-positive]]

-Anaplastic large-cell lymphoma, ALK-*

-Breast implant-associated anaplastic large-cell lymphoma*


**Hodgkin lymphoma [#ua765d0e]

Hodgkin lymphoma
-Nodular lymphocyte predominant Hodgkin lymphoma
-Classical Hodgkin lymphoma
--Nodular sclerosis classical Hodgkin lymphoma
--Lymphocyte-rich classical Hodgkin lymphoma
--Mixed cellularity classical Hodgkin lymphoma
--Lymphocyte-depleted classical Hodgkin lymphoma

**Posttransplant lymphoproliferative disorders (PTLD) WHO2016 [#p710fb51]

-Plasmacytic hyperplasia PTLD

-Infectious mononucleosis PTLD

-Florid follicular hyperplasia PTLD*

-Polymorphic PTLD

-Monomorphic PTLD (B- and T-/NK-cell types)

-Classical Hodgkin lymphoma PTLD

**Histiocytic and dendritic cell neoplasms [#j902ed7c]

-Histiocytic sarcoma

-Langerhans cell histiocytosis

-Langerhans cell sarcoma

-Indeterminate dendritic cell tumor

-Interdigitating dendritic cell sarcoma

-Follicular dendritic cell sarcoma

-Fibroblastic reticular cell tumor

-Disseminated juvenile xanthogranuloma

-Erdheim-Chester disease*

*血液腫瘍病理学のお勉強 [#wb4f2cec]

-[[Aplastic anemia (AA)]]

**日本病理学会 [#p1095d6a]

**日本血液病理研究会 [#se00f6e4]

**日本網内系学会 [#yb39882f]

***リンパ腫スキルアップセミナー [#xa1e1142]

**日本病理学会中部支部交見会血液関連症例 [#rdc57bf0]

**日本病理学会中部支部スライドセミナ血液関連セミナ [#sf39044b]

**日本血液学会 [#z23571e1]

[[日本血液学会公式ホームページ:http://www.jshem.or.jp/]] クリックで移動


**東京骨髄病理研究会 [#yaf6a3ae]

東京骨髄病理研究会の管理人まとめページ

[[第6回東京骨髄病理研究会]]

[[第5回東京骨髄病理研究会]]

[[第4回東京骨髄病理研究会]]

[[第3回東京骨髄病理研究会]]

[[第2回東京骨髄病理研究会]]

[[第1回東京骨髄病理研究会]]

**関東リンパ腫診断研究会(リンフォマニアの会) [#t304d25d]

[[リンフォマニアになるためのリンパ腫病理診断コース]]

[[東海大学公式のリンフォマニアになるためのリンパ腫病理診断コースホームページ:http://path.med.u-tokai.ac.jp/nakamura/lymphoma/index.html]] クリックで移動



Mature B-cell neoplasms
-Chronic lymphocytic leukemia/small lymphocytic lymphoma

-Monoclonal B-cell lymphocytosis*

-B-cell prolymphocytic leukemia

-Splenic marginal zone lymphoma

-Hairy cell leukemia

-Splenic B-cell lymphoma/leukemia, unclassifiable

--Splenic diffuse red pulp small B-cell lymphoma

--Hairy cell leukemia-variant

-Lymphoplasmacytic lymphoma

--Waldenstrom macroglobulinemia

-Monoclonal gammopathy of undetermined significance (MGUS), IgM*

-μ heavy-chain disease

-γ heavy-chain disease

-α heavy-chain disease

-Monoclonal gammopathy of undetermined significance (MGUS), IgG/A*

-Plasma cell myeloma

-Solitary plasmacytoma of bone

-Extraosseous plasmacytoma

-Monoclonal immunoglobulin deposition diseases*

-Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)

-Nodal marginal zone lymphoma

--Pediatric nodal marginal zone lymphoma

-Follicular lymphoma

--In situ follicular neoplasia*

--Duodenal-type follicular lymphoma*

-Pediatric-type follicular lymphoma*

-Large B-cell lymphoma with IRF4 rearrangement*

-Primary cutaneous follicle center lymphoma

-Mantle cell lymphoma

--In situ mantle cell neoplasia*

-Diffuse large B-cell lymphoma (DLBCL), NOS

--Germinal center B-cell type*

--Activated B-cell type*

-T-cell/histiocyte-rich large B-cell lymphoma

-Primary DLBCL of the central nervous system (CNS)

-Primary cutaneous DLBCL, leg type

-EBV+ DLBCL, NOS*

-EBV+ mucocutaneous ulcer*

-DLBCL associated with chronic inflammation

-Lymphomatoid granulomatosis

-Primary mediastinal (thymic) large B-cell lymphoma

-Intravascular large B-cell lymphoma

-ALK+ large B-cell lymphoma

-Plasmablastic lymphoma

-Primary effusion lymphoma

-HHV8+ DLBCL, NOS*

-Burkitt lymphoma

-Burkitt-like lymphoma with 11q aberration*

-High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements*

-High-grade B-cell lymphoma, NOS*

-B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma



Mature T and NK neoplasms
-T-cell prolymphocytic leukemia
-T-cell large granular lymphocytic leukemia
-Chronic lymphoproliferative disorder of NK cells
-Aggressive NK-cell leukemia
-Systemic EBV+ T-cell lymphoma of childhood*
-Hydroa vacciniforme-like lymphoproliferative disorder*
-Adult T-cell leukemia/lymphoma
-[[Extranodal Natural Killer(NK)/T-Cell Lymphoma, Nasal Type]]
-Enteropathy-associated T-cell lymphoma
-Monomorphic epitheliotropic intestinal T-cell lymphoma*
-Indolent T-cell lymphoproliferative disorder of the GI tract*
-Hepatosplenic T-cell lymphoma
-Subcutaneous panniculitis-like T-cell lymphoma
-Mycosis fungoides
-Sezary syndrome
-Primary cutaneous CD30+ T-cell lymphoproliferative disorders
--Lymphomatoid papulosis
--Primary cutaneous anaplastic large cell lymphoma
-Primary cutaneous γδ T-cell lymphoma
-Primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma
-Primary cutaneous acral CD8+ T-cell lymphoma*
-Primary cutaneous CD4+ small/medium T-cell lymphoproliferative disorder*
-Peripheral T-cell lymphoma, NOS
-Angioimmunoblastic T-cell lymphoma
-Follicular T-cell lymphoma*
-Nodal peripheral T-cell lymphoma with TFH phenotype*
-Anaplastic large-cell lymphoma, ALK+
-Anaplastic large-cell lymphoma, ALK-*
-Breast implant-associated anaplastic large-cell lymphoma*
Hodgkin lymphoma
-Nodular lymphocyte predominant Hodgkin lymphoma
-Classical Hodgkin lymphoma
--Nodular sclerosis classical Hodgkin lymphoma
--Lymphocyte-rich classical Hodgkin lymphoma
--Mixed cellularity classical Hodgkin lymphoma
--Lymphocyte-depleted classical Hodgkin lymphoma
Posttransplant lymphoproliferative disorders (PTLD)
-Plasmacytic hyperplasia PTLD
-Infectious mononucleosis PTLD
-Florid follicular hyperplasia PTLD*
-Polymorphic PTLD
-Monomorphic PTLD (B- and T-/NK-cell types)
-Classical Hodgkin lymphoma PTLD
Histiocytic and dendritic cell neoplasms
-Histiocytic sarcoma
-Langerhans cell histiocytosis
-Langerhans cell sarcoma
-Indeterminate dendritic cell tumor
-Interdigitating dendritic cell sarcoma
-Follicular dendritic cell sarcoma
-Fibroblastic reticular cell tumor
-Disseminated juvenile xanthogranuloma
-Erdheim-Chester disease*



Lymphomatoid granulomatosis SPS218-Case01





Myeloproliferative neoplasms (MPN)
-Chronic myeloid leukemia (CML), BCR-ABL1+

-Chronic neutrophilic leukemia (CNL)

-Polycythemia vera (PV)

-Primary myelofibrosis (PMF)

--PMF, prefibrotic/early stage

--PMF, overt fibrotic stage

-Essential thrombocythemia (ET)

-Chronic eosinophilic leukemia, not otherwise specified (NOS)

-MPN, unclassifiable

Mastocytosis

Myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2

-Myeloid/lymphoid neoplasms with PDGFRA rearrangement

-Myeloid/lymphoid neoplasms with PDGFRB rearrangement

-Myeloid/lymphoid neoplasms with FGFR1 rearrangement

-Provisional entity: Myeloid/lymphoid neoplasms with PCM1-JAK2

Myelodysplastic/myeloproliferative neoplasms (MDS/MPN)

-Chronic myelomonocytic leukemia (CMML)

-Atypical chronic myeloid leukemia (aCML), BCR-ABL1-

-Juvenile myelomonocytic leukemia (JMML)

-MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T)

-MDS/MPN, unclassifiable

Myelodysplastic syndromes (MDS)

-MDS with single lineage dysplasia

-MDS with ring sideroblasts (MDS-RS)

--MDS-RS and single lineage dysplasia

--MDS-RS and multilineage dysplasia

-MDS with multilineage dysplasia

-MDS with excess blasts

-MDS with isolated del(5q)

-MDS, unclassifiable

-Provisional entity: Refractory cytopenia of childhood

Myeloid neoplasms with germ line predisposition

Acute myeloid leukemia (AML) and related neoplasms

-AML with recurrent genetic abnormalities

--AML with t(8;21)(q22;q22.1);RUNX1-RUNX1T1

--AML with inv(16)(p13.1q22) or t(16;16)(p13.1;q22);CBFB-MYH11

--APL with PML-RARA

--AML with t(9;11)(p21.3;q23.3);MLLT3-KMT2A

--AML with t(6;9)(p23;q34.1);DEK-NUP214

--AML with inv(3)(q21.3q26.2) or t(3;3)(q21.3;q26.2); GATA2, MECOM

--AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1

--Provisional entity: AML with BCR-ABL1

--AML with mutated NPM1

--AML with biallelic mutations of CEBPA

--Provisional entity: AML with mutated RUNX1

-AML with myelodysplasia-related changes

-Therapy-related myeloid neoplasms

-AML, NOS

--AML with minimal differentiation

--AML without maturation

--AML with maturation

--Acute myelomonocytic leukemia

--Acute monoblastic/monocytic leukemia

--Pure erythroid leukemia

--Acute megakaryoblastic leukemia

--Acute basophilic leukemia

--Acute panmyelosis with myelofibrosis

-Myeloid sarcoma

-Myeloid proliferations related to Down syndrome

--Transient abnormal myelopoiesis (TAM)

--Myeloid leukemia associated with Down syndrome

Blastic plasmacytoid dendritic cell neoplasm

Acute leukemias of ambiguous lineage

-Acute undifferentiated leukemia

-Mixed phenotype acute leukemia (MPAL) with t(9;22)(q34.1;q11.2); BCR-ABL1

-MPAL with t(v;11q23.3); KMT2A rearranged

-MPAL, B/myeloid, NOS

-MPAL, T/myeloid, NOS

B-lymphoblastic leukemia/lymphoma

-B-lymphoblastic leukemia/lymphoma, NOS

-B-lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities

-B-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2);BCR-ABL1

-B-lymphoblastic leukemia/lymphoma with t(v;11q23.3);KMT2A rearranged

-B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1); ETV6-RUNX1

-B-lymphoblastic leukemia/lymphoma with hyperdiploidy

-B-lymphoblastic leukemia/lymphoma with hypodiploidy

-B-lymphoblastic leukemia/lymphoma with t(5;14)(q31.1;q32.3) IL3-IGH

-B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3);TCF3-PBX1

-Provisional entity: B-lymphoblastic leukemia/lymphoma, BCR-ABL1-like

-Provisional entity: B-lymphoblastic leukemia/lymphoma with iAMP21

T-lymphoblastic leukemia/lymphoma

-Provisional entity: Early T-cell precursor lymphoblastic leukemia

Provisional entity: Natural killer (NK) cell lymphoblastic leukemia/lymphoma

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